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No precise dose adjustment suggested when tofacitinib coadministered with potent CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with equally moderate CYP3A4 and powerful CYP2C19 inhibitors .crizotinib raises levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction could be desire
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